Use and Maintenance of Solvent Filter

The solvent filter( 300mL Glass Solvent Filter and 500ml Glass Solvent Filtration Apparatus) is a common experimental equipment in chemical laboratories, and it is an indispensable piece of equipment in liquid chromatographic analysis. In the chromatographic analysis, impurities that affect the life of the chromatographic column and the detection accuracy of the system can be removed, and it’s important for protecting the chromatographic column and the use of the chromatograph. It is widely used in laboratory chromatographic analysis. It plays a key role in extending the service life of the instrument and the chromatographic column and improving the detection accuracy. According to experimental requirements, different types of membranes are used for solvent filtration. The device is lined with a microporous membrane, which can be used for chemical analysis, instrument analysis, sanitary inspection, the pharmaceutical industry, biological products and pesticides, petroleum, environmental protection, and other aspects of liquid filtration to detect and remove particles and bacteria in the liquid.

Use of Solvent Filter:

  1. Proper Installation:
    • Ensure the filter is correctly installed in the filtration system, following manufacturer instructions.
  2. Material Compatibility:
    • Confirm that the filter material is compatible with the solvent being used. Some solvents may be corrosive or incompatible with certain filter materials.
  3. Flow Rate Consideration:
    • Use a filter with an appropriate pore size and surface area to maintain the desired flow rate for your application.
  4. Change-out Schedule:
    • Establish a regular schedule for changing the filter to prevent clogging and maintain filtration efficiency.
  5. Avoid Overloading:
    • Do not exceed the recommended capacity or loading of the filter. Overloading can reduce filtration efficiency and potentially damage the filter.
  6. Pressure Monitoring:
    • Keep an eye on the pressure across the filter. A significant increase in pressure may indicate a clogged filter that needs replacement.


Solvent filter equipment should also be maintained in a timely manner, and the filter cloth in the gasification device should be checked frequently. Check it every half year and regularly lubricate. Before operation, an appropriate amount of oil should be added to the solvent filter to lubricate the activity. Check whether the component is loose or worn. If there is any problem or damage, replace it in time.
The mobile phases used in liquid chromatographs are generally organic and water phases. The water phase should be stored in a brown solvent bottle. Many customers will use transparent solvent bottles, especially mobile phases containing phosphate buffer systems. Will cause the growth of algae.

  1. Regular Inspection:
    • Visually inspect the filter for signs of wear, damage, or clogging. Replace any damaged or worn-out parts promptly.
  2. Cleaning:
    • Some filters can be cleaned and reused. Follow manufacturer guidelines for proper cleaning procedures.
  3. Sterilization (if applicable):
    • If the filter requires sterilization, follow the recommended sterilization methods provided by the manufacturer.
  4. Storage:
    • Store filters in a clean, dry environment, away from contaminants and extreme temperatures.
  5. Record Keeping:
    • Maintain records of filter usage, changes, and any issues encountered. This helps track the performance and lifespan of the filter.
  6. Training and Education:
    • Ensure that personnel handling the filtration system are properly trained on the use and maintenance of the solvent filter.
  7. Follow Manufacturer Guidelines:
    • Adhere to specific maintenance instructions provided by the filter manufacturer to ensure optimal performance.


Some operators open the solvent bottle directly or simply cover it, and some customers use methanol and acetonitrile for mobile phase preparation which are themselves substandard. After some time, the solvent filter will be clogged, and the instrument will become abnormal with rising pressure. If so, cleaning is required.
In summary, prevention is the key point. Cleaning is only a last resort. If it is not clean, you need to replace it with a new one.

  • Remove the solvent filter from the street of the pipeline.
  • Prepare pure water to clean the remaining mobile phase.
  • Use 35% concentrated nitric acid to soak the filter for about 1 hour.
  • Use pure water to clean it, or the chromatographic column will be damaged.
  • Put the filter back in place

Please note no ultrasonic cleaner is used for the cleaning of the glass solvent filter, otherwise, it may shatter and cause blockage.